Session 3:  Cancer therapeutic innovations

Glutamine sensing in pancreatic cancer: from mechanisms of action to therapeutic perspectives

Pancreatic cancer remains one of the most lethal malignancies, underscoring the urgent need for innovative therapeutic approaches. Emerging evidence highlights glutamine metabolism as a crucial factor in supporting pancreatic cancer cell growth and survival, offering new opportunities for intervention. This presentation explores the molecular mechanisms underlying glutamine sensing in pancreatic cancer, with a focus on its role in nutrient availability signaling, metabolic reprogramming, and tumor progression. By dissecting the regulatory pathways, including post-translational modifications such, we shed light on key players and their interactions with metabolic and signaling networks. We wil discuss the translational potential of targeting glutamine metabolism to improve therapeutic strategies, paving the way for more effective treatments in pancreatic cancer.