Session 2:  Microenvironment and resistance 

Tumour-stroma interactions in pancreatic cancer metastasis: Mechanisms and therapeutic opportunities

Our Liverpool Tumour Microenvironment team focuses on understanding the tumour-stroma interactions in pancreatic cancer and how these affect pancreatic cancer metastasis and response to therapies. To address these important questions, we use a variety of co-culture models, in vivo models and patient-derived tumour explants that we interrogate integrating omics technologies, multiplexing imaging and bioinformatic analysis.

In this presentation I will provide an overview of our research programme and findings focusing in particular into a therapeutic target we have recently identified as a key driver of PDAC metastatic relapse after chemotherapy treatment and that we are currently translating into patients.